Journal article
Association of medically assisted reproduction with offspring cord blood DNA methylation across cohorts
D Caramaschi, J Jungius, CM Page, B Novakovic, R Saffery, J Halliday, S Lewis, MC Magnus, SJ London, SE Håberg, CL Relton, DA Lawlor, HR Elliott
Human Reproduction | Published : 2021
Abstract
STUDY QUESTION: Is cord blood DNA methylation associated with having been conceived by medically assisted reproduction? SUMMARY ANSWER: This study does not provide strong evidence of an association of conception by medically assisted reproduction with variation in infant blood cell DNA methylation. WHAT IS KNOWN ALREADY: Medically assisted reproduction consists of procedures used to help infertile/subfertile couples conceive, including ART. Due to its importance in gene regulation during early development programming, DNA methylation and its perturbations associated with medically assisted reproduction could reveal new insights into the biological effects of assisted reproductive technologie..
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Grants
Awarded by Seventh Framework Programme
Funding Acknowledgements
This study has also been supported by the US National Institute of Health (R01 DK10324), the European Research Council under the European Union's Seventh Framework Programme (FP7/2007-2013)/ERC Grant agreement no. 669545, European Union's Horizon 2020 research and innovation programme under Grant agreement no. 733206 (LifeCycle) and the NIHR Biomedical Centre at the University Hospitals Bristol NHS Foundation Trust and the University of Bristol. The UK Medical Research Council and Wellcome (Grant ref: 102215/2/13/2) and the University of Bristol provide core support for ALSPAC. A comprehensive list of grants funding is available on the ALSPAC website (http://www.bristol.ac.uk/alspac/external/docu ments/grant-acknowledgements.pdf). Methylation data in the ALSPAC cohort were generated as part of the UK BBSRC funded (BB/I025751/1 and BB/I025263/1) Accessible Resource for Integrated Epigenomic Studies (ARIES, http://www.ariesepigenomics.org.uk).ALSPAC GWAS data was generated by Sample Logistics and Genotyping Facilities at Wellcome Sanger Institute and LabCorp (Laboratory Corporation of America) using support from 23andMe. D.C., J.J., C.L.R. D.A.L and H.R.E. work in the MRC Integrative Epidemiology Unit at the University of Bristol, supported by the UK Medical Research Council and the University of Bristol (Grant nos. MC_UU_00011/1, MC_UU_00011/5, MC_UU_00011/6). B.N. is supported by an NHMRC (Australia) Investigator Grant (1173314). The Norwegian Mother, Father and Child Cohort Study is supported by the Norwegian Ministry of Health and Care Services and the Ministry of Education and Research, NIH/NIEHS (Contract no N01-ES-75558), NIH/NINDS (Grant nos. (i) UO1 NS 047537-01 and (2) UO1 NS 047537-06A1). For this work, MoBa 1 and 2 were supported by the Intramural Research Program of the NIH, National Institute of Environmental Health Sciences (Z01-ES-49019) and the Norwegian Research Council/BIOBANK (Grant no. 221097). This work was partly supported by the Research Council of Norway through its Centres of Excellence funding scheme, project number 262700.